Scientist (Epigenetics) : Lyon, France

Temps complet | 6 mois | Date limite: 05 mars 2018 00h 00min 00s
Cette position a expiré. Ne pas appliquer!

Résumé de l'emploi

Temps complet
Postgraduate - Doctorate/PhD

Description de poste


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The International Agency for Research on Cancer (IARC) offers unique opportunities to study the burden, causes and prevention of cancer worldwide. IARC specializes in the integration of laboratory and population-based sciences and in coordinating and conducting multi-center studies.

Job description:

The Agency is recruiting an experienced research Scientist to join its Epigenetics Group (EGE):

Scientist (Epigenetics)

In summary, the incumbent will carry out existing and develop new studies aimed at testing mechanistic hypothesis on the role of early molecular events and deregulated pathways involved in tumour initiation and progression, which should advance our knowledge of mechanisms of carcinogenesis.

This will involve, but not limited to, the discovery and characterization of functionally important epigenetic “driver” genes (“epidrivers”) and molecular pathways altered by specific carcinogenic agents as well as the development and application of in vitro models (human and mouse immortalization models) and state-of-the-art approaches, (epi)genome editing (such as CRISPR/Cas9 technology), genome-wide shRNA library knockdown screens, cell phenotyping and functional (epi)genomics. He/she will also participate in collaborative projects across IARC aimed at better understanding the mechanisms of carcinogenesis and of the causal pathways underlying specific malignancies.

The key duties of the incumbent include:

1/ Contribute to the development, design, and conduct of research projects aiming to better understand the role of epigenetic mechanisms in cancer development and progression and to discover/validate epigenetic biomarkers of exposure and cancer.

2/ Assist in the development of epigenetic assays that may facilitate evaluation of new potential carcinogens and incorporation of epigenetic data into carcinogen evaluation by the IARC Monographs Programme.

3/ Coordinate laboratory experiments related to ongoing molecular/cell biology studies and liaise with relevant internal and external groups and networks. Seek and develop collaborations with other researchers at IARC where epigenetic approaches may add value to research projects.

4/ Prepare and write scientific manuscripts, reviews, and reports based on on-going and future mechanistic and profiling studies.

5/ Contribute to writing grant applications in the relevant research areas with a view to attracting research funding from competitive sources.

6/ Provide technical advice and daily supervision to post-doctoral fellows, students, visitors and trainees hosted by the EGE Group.

More information about the EGE Group at IARC can be found at the following link:
http://www.iarc.fr/en/research-groups/EGE/index.php
Full details on this position and the link to submit online applications can be accessed via the requisition notice (REQ-1800377) published on the IARC Internet site at: http://www.iarc.fr under “Jobs & Careers/Professional Staff”.

Requirements:

1) PhD (doctoral degree) or Doctor of Medicine (MD) degree in molecular biology, genetics, genomics, cancer biology, or related field.

2) Applied knowledge in modern molecular/cell biology and (epi)genomics in particular with respect to cancer research.

3) At least two years’ post-doctoral experience within the field of cancer research related to epigenetics/epigenomics, molecular biology and functional (epi)genomics.

4) Experience of working on mechanistic/functional studies using in vitro (cell culture) models.

5) Experience with bioinformatics and related skill set, experimental setup for genome-editing and multiparametric phenotyping as well as other state-of-the-art tools of molecular and cell biology (such as shRNA library knockdown screens) would be an asset.

6) Solid publication record in the relevant research areas.

Additional Information:

Only applications submitted via our online recruitment tool accessible from the requisition notice published on our Internet site will be considered.

Deadline for submitting applications: Monday 5 March 2018

It is mandatory to attach a full list of publications. To add this list, please go to your profile under the “publication” tab.

All candidates are strongly encouraged to add a cover letter to their online application.
Candidates called for interview will be expected to give a seminar.

Remuneration:

Remuneration for WHO/IARC staff in the Professional and higher category is quoted in US dollars.
The fixed remuneration for the above position comprises an annual net salary plus a post adjustment which reflects the cost of living in a particular duty station.

Total fixed remuneration for this position currently amounts to USD 70926 per annum which is the sum of:

1) annual net salary of USD 46026 at Level P2/Step I of the UN professional salary scale, plus 2) post adjustment for Lyon, France currently amounting to an annualized figure of USD 24900.

The fixed remuneration is expressed net of income tax but before deduction of the employee share contributions for mandatory participation in the United Nations Joint Staff Pension Fund and in the Organization’s private insurance plans covering health, accident, illness and disability.

Other benefits include 30 days of annual leave and allowances for dependent family members.

Subject to certain conditions, internationally-recruited staff may also be entitled to relocation travel & shipment, settling-in grant upon appointment, home leave and/or education grant for dependent children.

More information about the remuneration and benefit package applicable at WHO/IARC can be found at the following link: http://www.who.int/careers/what-we-offer/en/


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