Post-Doctoral Position in mammalian epigenetics: linking DNA replication and DNA methylation CNRS : Paris, France

Temps complet | Paris 15, LE DE FRANCE | 10 jours | Date limite: 14 juillet 2018 00h 00min 00s

Résumé de l'emploi

Temps complet
Postgraduate - Doctorate/PhD

Description de poste


  • Tweet
  • Facebook
  • LinkedIn
  • Google+

A post-doctoral position funded for 2 years is available in our group. We study epigenetic regulators in mammalian cells; more precisely we are interested in the modifications of DNA (methylation, hydroxymethylation, …), the proteins that recognize epigenetically modified DNA, and the functional consequences of these phenomena.

The funded project investigates the dynamics of DNA remethylation in mammalian cells during DNA replication. More specifically, the project focuses on UHRF1, an essential protein that promotes epigenetic memory. We have identified a new mechanism by which UHRF1 is recruited to replicating DNA (Ferry et al Mol Cell 2017). We now wish to expand these findings and systematically identify the mechanisms promoting DNA methylation maintenance on the two replicating strands of DNA. The methods employed include cell culture, CRISPR mutagenesis, whole-genome methylation analyses, proteomics, and live-cell imaging.

The project is a close collaboration with an expert in DNA replication: Marie-Noëlle Prioleau, at the neighboring Jacques Monod Institute (https://www.ijm.fr/en/94/equipes ).

Our group is part of a highly successful department devoted to Epigenetics and Cell Fate. The workplace is friendly and international and the working language is English. We are located in a recent research facility in a vibrant area of Paris. The campus houses a cluster of Life Sciences institutes and provides access to state-of-the-art facilities including Genomics, Proteomics, and Imaging. Visit our website http://parisepigenetics.com/ for more details on the lab and our research interests. Informal enquiries by email to PA Defossez are also welcome if you want to find out more.

A doctoral degree, experience in cellular and molecular biology, and proficiency in English, are required. Candidates must be highly motivated, interactive, and have a successful track record.

Applications will be considered until the position is filled. To apply, please send your CV, a motivation letter, and the names of two references to:

Pierre-Antoine.Defossez@univ-paris-diderot.fr


Emplois Similaires

  • Account Manager Biotech - Lyon Area, France-BIO000536 About Us Pall Corporation is a global leader in high-tech filtration, separation, and purification, serving the diverse needs of customers...

  • Level of Education Secondary professional education Areas of study Food and beverage Languages essential French Vous contribuez au bon déroulement du service et à la qualité de la production en...

  • Level of Education Secondary professional education Areas of study Food and beverage Professional experiences 1 to 2 years Languages essential French En tant que chef de rang vous assurez et...

  • Level of Education A level Areas of study Cooking Professional experiences 3 to 5 years Languages essential French Venez rejoindre une équipe de professionnels et une créer cuisine innovante en...

  • Level of Education Secondary professional education Areas of study Hospitality Professional experiences 1 to 2 years Languages essential French English At Novotel, we grow faster Feel fully...

  • Facilities Manager-18000KWZ Preferred Qualifications Responsibilities: 1) Managerial a) Manage and supervise staff in multiple locations in a specific geographic area. b) Effectively manage the...


Emplois Similaires

Partager